Smoking and cognitive function in Parkinson's disease
Identifieur interne : 000F53 ( Main/Exploration ); précédent : 000F52; suivant : 000F54Smoking and cognitive function in Parkinson's disease
Auteurs : Marc G. Weisskopf [États-Unis] ; Francine Grodstein [États-Unis] ; Alberto Ascherio [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-04-15.
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Abstract
The risk of dementia among Parkinson's disease (PD) patients is greatly elevated compared to controls, yet little is known about determinants of cognitive function among PD patients. We assessed the relation between cigarette smoking prior to disease onset and later cognitive function among PD patients (n = 286) and age‐ and sex‐matched controls (n = 1144) participating in the Nurses' Health Study and Health Professionals Follow‐up Study. Both groups completed telephone‐administered assessments of cognitive function. We used linear regression to calculate mean differences in cognitive test scores across smoking categories, adjusted for age, education, sex, age at onset of PD, and years since diagnosis. PD patients scored significantly worse on all tests than their matched controls. In analyses only among PD cases, but not among controls, current smokers at PD onset scored worse than never smokers on the Telephone Interview for Cognitive Status (difference = −0.82, 95% CI: −1.33, −0.30, P = 0.002) as well as on a global score combining results of all tests (difference = −0.36, 95% CI: −0.72, 0.01, P = 0.06). This difference was equivalent to the difference in global score observed among controls ∼10 years apart in age. Analyses of pack‐years of smoking prior to disease onset gave similar results. These findings, nested in prospective cohort studies, suggest that cigarette smoking prior to disease onset is associated with worse cognitive function in PD. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21373
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Weisskopf</name></author><author><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:188A3F3DF11C785D336F1660486D4B82C061190B</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21373</idno><idno type="url">https://api.istex.fr/document/188A3F3DF11C785D336F1660486D4B82C061190B/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002B24</idno><idno type="wicri:Area/Main/Curation">002759</idno><idno type="wicri:Area/Main/Exploration">000F53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Smoking and cognitive function in Parkinson's disease</title><author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-04-15">2007-04-15</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="660">660</biblScope><biblScope unit="page" to="665">665</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">188A3F3DF11C785D336F1660486D4B82C061190B</idno><idno type="DOI">10.1002/mds.21373</idno><idno type="ArticleID">MDS21373</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognitive function</term><term>epidemiology</term><term>prospective studies</term><term>risk factors</term><term>smoking</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The risk of dementia among Parkinson's disease (PD) patients is greatly elevated compared to controls, yet little is known about determinants of cognitive function among PD patients. We assessed the relation between cigarette smoking prior to disease onset and later cognitive function among PD patients (n = 286) and age‐ and sex‐matched controls (n = 1144) participating in the Nurses' Health Study and Health Professionals Follow‐up Study. Both groups completed telephone‐administered assessments of cognitive function. We used linear regression to calculate mean differences in cognitive test scores across smoking categories, adjusted for age, education, sex, age at onset of PD, and years since diagnosis. PD patients scored significantly worse on all tests than their matched controls. In analyses only among PD cases, but not among controls, current smokers at PD onset scored worse than never smokers on the Telephone Interview for Cognitive Status (difference = −0.82, 95% CI: −1.33, −0.30, P = 0.002) as well as on a global score combining results of all tests (difference = −0.36, 95% CI: −0.72, 0.01, P = 0.06). This difference was equivalent to the difference in global score observed among controls ∼10 years apart in age. Analyses of pack‐years of smoking prior to disease onset gave similar results. These findings, nested in prospective cohort studies, suggest that cigarette smoking prior to disease onset is associated with worse cognitive function in PD. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name></region><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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